“Inorganic Chemistry of Radiometals”

Prof.sse Boschi e Martini

04/02 ore 10-13
06/02 ore 10-13
11/02 ore 10-13
13/02 ore 10-1317/02 ore 10-13
18/02 ore 10-13

L'aula verrà comunicata al più presto agli studenti interessati al corso.

Course content:

The course aims to provide an overview of the production techniques and use of radiometals and radiopharmaceuticals
for diagnostic and therapeutic applications in medicine. The course provides the theoretical basis on radioactivity,
radiometal production methods, radiochemical separation techniques, automation of radiochemical procedures,
radiopharmaceutical production and applications in nuclear medicine.
The course consists of 3 modules of 6 hours each for a total of 18 hours of lessons.
The contents of the first module will cover basic concepts on: radioactivity and radiation, radioactive decay, and the
kinetics of radioactive decay.

The contents of the second module will address modern methods and technologies used in the production and separation
of radiometals for medical use, as well as the automation of radiopharmaceutical synthesis.
The contents of the third module will focus on the chemistry and synthesis of the most widely used
radiopharmaceuticals for SPET (Single Photon Emission Tomography), PET (Positron Emission Tomography) and for
therapy in the field of medical diagnosis and nuclear therapy.

Primo e secondo modulo (docente: Dott.ssa Petra Martini)

Terzo modulo (docente: Dott.ssa Alessandra Boschi)

Delivery Nanosystems: design, characterization and biological targeting. The aim of the course is to deepen the knowledge on the development of delivery nanosystems for the oral, nasal and topical administration of drugs and to evaluate their interaction with target organs. The course will be structured in three sections: the first part will focus on the physical-chemical characterization of the different delivery nanosystems (composition and characterization); the second part will describe principles of pharmacokinetics and bioavailability in
relation to different forms of administration of active ingredients; the third part will deepen the interaction between the
nanosystems with the target organs (cutaneous tissue, gastro-intestinal tract and respiratory tract). In particular, the
contents of the course will be organized as follow:

Primo modulo (4 ore):
• Study of the composition of the different nanosystems (particles, vesicles, organic, inorganic, lipid- or
polymeric-based)
• Physical-chemical characterization of nanosystems
• Analysis of drug release kinetic in vitro
Secondo modulo (4 ore):
• Intravenous and oral administration of drugs, determination of drug half-life, elimination constant and
bioavailability
• Extractive and analytical procedures for the quantification of active ingredients in the bloodstream
• Biological barriers between the blood and the central nervous system (CNS)
• Nasal formulations for the targeting of active ingredients to the CNS
Terzo modulo (4 ore):

• Anatomy of the cutaneous tissue, the gastro-intestinal tract and the respiratory district
• Interaction between nanosystems and biological barriers: absorption, distribution, and excretion
• Use of in-vitro/ex-vivo models and use of the main analytical techniques for the evaluation of the

interaction between the nanosystems and the biological targets

obbligatoria la presenza ad almeno 2/3 delle lezioni; è possibile attivare il collegamento in streaming solo per
chi si trova all'estero per motivi di studio/ricerca.